|Glycerides of Butyric acid|
Via esterification a fatty acid can be linked to glycerol of which fat molecules arises. In a similar way Monobutyrin is an esterification of butyric acid and glycerol which creates a monoglyceride of butyric acid with polar properties. Because of these properties, monobutyrin is capable of passing the hydrophilic membrane of important pathogenic bacteria (E. Coli, Salmonella, Clostridium perfringens), invade the bacteria cell and eliminate it. Monoglycerides of organic acids are up to 30 times more effective against bacteria than their original acid.
Because the mono-glyceride is soluble in water, you see immediately an antibacterial effect in drinking water, feed, mouth and stomach / crop. Besides the strong efficacy against bacteria, the new molecule also provides a fungal inhibition similar to propionic acid. This allows the monobutyrin to replace the fungus inhibitor which will reduce the additional costs of the monobutyrin.
This mono-glyceride can be used in each specie and until today we have seen no negative effects on feed intake. Even with an extremely high dosage. The feed intake even increases if the other organic acids are being replaced.
There are no restrictions regarding the period of use and the product is used anti-bacterial in a curative dose as well as in a preventative dose. With a curative dose, the product is efficiently used against Salmonella clostridiosis, E-coli, Lawsonia and colitis. With a preventive dosage, the product showed strong efficacy against coccidiosis, ileitis, Salmonellosis, clostridiosis, necrotic enteritis and colon inflammation.
Because of the many achievements in practice and research, we know that the glycerides of butyric acid have a very good influence on the intestinal health and overall health of the animal. This results in a better digestibility, better feed conversion, reduced mortality and less medication use.
Finally, monobutyrin is odorless and non-corrosive which is a big advantage in the processing of this product compared to other sources of butyric acid.
Baby C4 is a blend of mono-, di-, and tri-glycerides of butyric acid which is apolar and in high doses having a negative impact on palatability. It is, unlike the monoglyceride of butyric acid, less effective in eliminating bacteria in the stomach. However, this blend has the following unique features:
1) It fuels the gut mucosa cells by providing extra energy in the gut and consequently plays an important role in the proliferation and differentiation of the epithelial cells
2) It stimulates the development of a favourable intestinal flora (e.g. Lactobacilli)
3) It reduces the colonization and invasiveness of Salmonella in the gut (caeca)
4) It reduces the risks for incidence such as necrotic enteritis (Clostridium perfringens) and Colibacillosis.
1) It enhances the barrier function of the intestinal epithelium since butyrate up-regulates the expression of tight junction proteins (=’glue’ joining the epithelial cells together)
Butyric acid is in low concentrations present in the intestinal tract. Baby C4 ensures a proper amount of butyric acid in the intestines to improve the growth of the villi.
Baby C4 in pigs does not affect the feed intake negatively if the dosage doesn’t exceed 2 kg per ton of feed.